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Greene, Geoffrey
One or more keywords matched the following items that are connected to Greene, Geoffrey
Item TypeName
Concept Tumor Necrosis Factor-alpha
Concept GTP-Binding Protein alpha Subunits, Gs
Concept Hepatocyte Nuclear Factor 3-alpha
Concept Transforming Growth Factor alpha
Concept GTP-Binding Protein alpha Subunits, Gq-G11
Concept Estrogen Receptor alpha
Academic Article Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Academic Article Plasma membrane estrogen receptors exist and functions as dimers.
Academic Article Structural basis for an unexpected mode of SERM-mediated ER antagonism.
Academic Article Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.
Academic Article An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
Academic Article A structural explanation for ERalpha/ERbeta SERM discrimination.
Academic Article Estrogen-dependent and -independent estrogen receptor-alpha signaling separately regulate male fertility.
Academic Article Characterization of the ovarian and reproductive abnormalities in prepubertal and adult estrogen non-responsive estrogen receptor alpha knock-in (ENERKI) mice.
Academic Article Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha.
Academic Article Molecular characterization of a B-ring unsaturated estrogen: implications for conjugated equine estrogen components of premarin.
Academic Article Modulation of alphaCaMKII signaling by rapid ERalpha action.
Academic Article Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
Academic Article Structural plasticity in the oestrogen receptor ligand-binding domain.
Academic Article CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
Academic Article RAC3 is a pro-migratory co-activator of ERa.
Academic Article Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.
Academic Article Prolactin activates ERa in the absence of ligand in female mammary development and carcinogenesis in vivo.
Academic Article Estrogen inhibits vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro.
Academic Article The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Academic Article Mapping ERß genomic binding sites reveals unique genomic features and identifies EBF1 as an ERß interactor.
Academic Article Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract.
Academic Article The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor a modulation, uncoupling nuclear and membrane activation.
Academic Article Cross-talk between the ligand- and DNA-binding domains of estrogen receptor.
Academic Article ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.
Academic Article Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Academic Article Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.
Academic Article The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Academic Article Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
Academic Article A "cross-stitched" peptide with improved helicity and proteolytic stability.
Academic Article Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
Academic Article Next-Generation ERa Inhibitors for Endocrine-Resistant ER+ Breast Cancer.
Academic Article Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.
Academic Article The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
Academic Article The NF-?B Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor-Positive Breast Cancers.
Academic Article The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells.
Academic Article Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.
Academic Article A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
Academic Article Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Academic Article Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line.
Concept Protein Conformation, alpha-Helical
Search Criteria
  • GTP Binding Protein alpha Subunits Gs